Critical growth factors and signalling pathways controlling human trophoblast invasion
نویسندگان
چکیده
منابع مشابه
Human Trophoblast Progenitor Cells Express and Release Angiogenic Factors
Trophoblast stem cells develop from polar trophoectoderm and give rise to the cells that generate the placenta. Trophoblast cells are responsible for the uterinal invasion and vascular remodeling during the implantation of the embryo. However this knowledge is not yet to be confirmed for trophoblast progenitor cells (TPCs). In this study, we aimed to demonstrate that human TPCs (hTPCs) express ...
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A critical step in establishment of human pregnancy is the invasion of the uterus wall by the extravillous cytotrophoblast (EVCT), a process regulated by multiple autocrine and paracrine factors. Hormones belonging to the GH/prolactin family are expressed at the maternofetal interface. Because they are involved in cell motility in various models, we examined the possible regulatory role of huma...
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The ligand-dependent nuclear receptors PPAR and RXR / were recently determined to be essential for murine placental development and trophoblast differentiation. In the current study we examined the expression and role of the PPAR / RXR heterodimers in human invasive trophoblasts. We first report that in human first trimester placenta, PPAR and RXR are highly expressed in cytotrophoblasts at the...
متن کامل(Epi)genetic control of human trophoblast invasion
During pregnancy the placenta is essential for the growing fetus as it provides oxygen and nutrients and accomplishes waste disposal by connecting the maternal and fetal circulations. To form a functional placenta the fetomaternal interface must be properly developed. For this, fetal extravillous trophoblasts need to invade the maternal placental bed thereby remodeling the maternal spiral arter...
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ژورنال
عنوان ژورنال: The International Journal of Developmental Biology
سال: 2010
ISSN: 0214-6282
DOI: 10.1387/ijdb.082769mk